ANTIBIOTICS FROM BASIDIOMYCETES. IX OUDEMANSIN, AN ANTIFUNGAL ANTIBIOTIC FROM <i>OUDEMANSIELLA MUCIDA</i> (SCHRADER ex FR.) HOEHNEL (AGARICALES)

TIMM ANKE; HANS JÜRGEN HECHT; GEORGS CHRAMM; WOLFGANG STEGLICH

doi:10.7164/antibiotics.32.1112

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

ANTIBIOTICS FROM BASIDIOMYCETES. IX

OUDEMANSIN, AN ANTIFUNGAL ANTIBIOTIC FROM OUDEMANSIELLA MUCIDA (SCHRADER ex FR.) HOEHNEL (AGARICALES)

TIMM ANKE, HANS JÜRGEN HECHT, GEORGS CHRAMM, WOLFGANG STEGLICH

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1979 Volume 32 Issue 11 Pages 1112-1117

DOI https://doi.org/10.7164/antibiotics.32.1112

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Abstract

From mycelial cultures of Oudemansiella mucida a crystalline optically active antibiotic, oudemansin (2), has been isolated; its structure is closely related to strobilurin A (1). The relative configuration of oudemansin have been determined by X-ray analysis. The antibiotic exhibits strong antifungal properties and inhibits respiration in fungi, cells of the ascitic form of EHRLICH carcinoma, and rat liver mitochondria.

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