FOUR FURTHER ANTIBIOTICS RELATED TO OLIVANIC ACID PRODUCED BY STREPTOMYCES OLIVACEUS: FERMENTATION, ISOLATION, CHARACTERISATION AND BIOSYNTHETIC STUDIES

Abstract

Four β-lactam antibiotics with β-lactamase inhibitory activity MM 22380, MM 22381,
MM 22382 and MM 22383 containing the carbapenem nucleus have been isolated from a
culture of Streptomyces olivaceus ATCC 31365. Fermentation conditions for their production
and methods for their isolation are described. Evidence for a biosynthetic link between these
compounds and the previously described olivanic acid derivatives MM 4550, MM 13902 and
MM 17880 is presented.