The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
SEMISYNTHETIC BICYCLOMYCIN DERIVATIVES: PREPARATION AND ANTIBACTERIAL EVALUATION
B. W. MÜLLERO. ZAKW. KUMPW. TOSCHO. WACKER
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1979 Volume 32 Issue 7 Pages 689-705

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Abstract

A number of semisynthetic bicyclomycin derivatives have been prepared by modifications at various sites of the molecule. The preparation, characterization and antimicrobial evaluation of the new compounds is described. In contrast to bicyclomycin itself, the new derivatives 48 and 58 are also active against Proteus species. Otherwise, the antibacterial potency of the bicyclomycin molecule was found to be very sensitive to structural changes.

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