ANTITUMOR ANTHRACYCLINE ANTIBIOTICS, ACLACINOMYCIN A AND ANALOGUES I. TAXONOMY, PRODUCTION, ISOLATION AND PHYSICOCHEMICAL PROPERTIES

TOSHIKAZU OKI; IWAO KITAMURA; AKIHIRO YOSHIMOTO; YASUE MATSUZAWA; NORIO SHIBAMOTO; TATSUO OGASAWARA; TAIJI INUI; AKIRA TAKAMATSU; TOMIO TAKEUCHI; TORU MASUDA; MASA HAMADA; HIROYUKI SUDA; MASAAKI ISHIZUKA; TSUTOMU SAWA; HAMAO UMEZAWA

doi:10.7164/antibiotics.32.791

ANTITUMOR ANTHRACYCLINE ANTIBIOTICS, ACLACINOMYCIN A AND ANALOGUES

I. TAXONOMY, PRODUCTION, ISOLATION AND PHYSICOCHEMICAL PROPERTIES

TOSHIKAZU OKI, IWAO KITAMURA, AKIHIRO YOSHIMOTO, YASUE MATSUZAWA, NORIO SHIBAMOTO, TATSUO OGASAWARA, TAIJI INUI, AKIRA TAKAMATSU, TOMIO TAKEUCHI, TORU MASUDA, MASA HAMADA, HIROYUKI SUDA, MASAAKI ISHIZUKA, TSUTOMU SAWA, HAMAO UMEZAWA

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JOURNAL FREE ACCESS

1979 Volume 32 Issue 8 Pages 791-800

DOI https://doi.org/10.7164/antibiotics.32.791

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Abstract

Aclacinomycin A and B, two major components of a new antitumor antibiotic complex, and their 19 analogues were produced by a culture of strain No. A144-M1, which was identified as Streptomyces galilaeus. They were isolated by chelation with copper ion and silicic acid chromatography, and characterized by physicochemical methods in the anthracycline group of antibiotics.

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