The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
BIS-TRIMETHYLSILYLCEFAMANDOLE: AN UNUSUALLY STABLE TRIMETHYLSILYL-INTERMEDIATE
WILLIAM J. WHEELERDON R. FINLEYHAROLD E. OSBORNE
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JOURNAL FREE ACCESS

1980 Volume 33 Issue 1 Pages 72-75

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Abstract

The preparation of crystalline bis-trimethylsilylcefamandole (7) and its utility in the preparation and purification of cefamandole are described. Although stable to solvolysis in isopropyl alcohol, 7 underwent smooth conversion to cefamandole in the presence of water, methanol, or ethanol.

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© Japan Antibiotics Research Association
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