PS-6 AND PS-7, NEW &ampbeta;-LACTAM ANTIBIOTICS ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURES

NORIO SHIBAMOTO; AKIHIKO KOKI; MASAYOSHI NISHINO; KOSUMI NAKAMURA; KOHKI KIYOSHIMA; KAZUHIKO OKAMURA; MITSUYASU OKABE; ROKURO OKAMOTO; YASUO FUKAGAWA; YASUTAKA SHIMAUCHI; TOMOYUKI ISHIKURA

doi:10.7164/antibiotics.33.1128

PS-6 AND PS-7, NEW β-LACTAM ANTIBIOTICS ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURES

NORIO SHIBAMOTO, AKIHIKO KOKI, MASAYOSHI NISHINO, KOSUMI NAKAMURA, KOHKI KIYOSHIMA, KAZUHIKO OKAMURA, MITSUYASU OKABE, ROKURO OKAMOTO, YASUO FUKAGAWA, YASUTAKA SHIMAUCHI, TOMOYUKI ISHIKURA

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JOURNAL FREE ACCESS

1980 Volume 33 Issue 10 Pages 1128-1137

DOI https://doi.org/10.7164/antibiotics.33.1128

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Abstract

Antibiotics PS-6 and PS-7 which are shown to be 5R, 6R-3-(2-acetamido)ethylthio-6-isopropyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and 5R, 6R-3-(E)-(2-acetamido) vinylthio-6-ethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid respectively, are new β-lactam compounds isolated from fermentation broths of Streptomyces cremeus subsp. auratilis A271, S. fulvoviridis A933, S. olivaceus ATCC 31126 and S. flavogriseus NRRL 8139. Fermentation, isolation, physicochemical properties and structures of antibiotics PS-6 and PS-7 are described.

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