MICROBIAL CONVERSION OF ε-PYRROMYCINONE AND ε-ISORHODOMYCINONE TO 1-HYDROXY-13-DIHYDRODAUNOMYCIN AND N-FORMYL-1-HYDROXY-13-DIHYDRODAUNOMYCIN AND THEIR BIOACTIVITIES

AKIHIRO YOSHIMOTO; YASUE MATSUZAWA; TOSHIKAZU OKI; HIROSHI NAGANAWA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.33.1150

AKIHIRO YOSHIMOTO, YASUE MATSUZAWA, TOSHIKAZU OKI, HIROSHI NAGANAWA, TOMIO TAKEUCHI, HAMAO UMEZAWA

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JOURNAL FREE ACCESS

1980 Volume 33 Issue 10 Pages 1150-1157

DOI https://doi.org/10.7164/antibiotics.33.1150

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Abstract

New anthracycline antibiotics, 1-hydroxy-13-dihydrodaunomycin and N-formyl-1-hydroxy-13-dihydrodaunomycin were biosynthesized by a blocked mutant of Streptomyces coeruleorubidus MEt30-A4 from ε-pyrromycinone or ε-isorhodomycinone.

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