BIOLOGICAL PROPERTIES OF NEW ACYL DERIVATIVES OF TYLOSIN

ROKURO OKAMOTO; MASAMI TSUCHIYA; HIDEO NOMURA; HIROSHI IGUCHI; KOHKI KIYOSHIMA; SENJI HORI; TAIJI INUI; TSUTOMU SAWA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.33.1309

ROKURO OKAMOTO, MASAMI TSUCHIYA, HIDEO NOMURA, HIROSHI IGUCHI, KOHKI KIYOSHIMA, SENJI HORI, TAIJI INUI, TSUTOMU SAWA, TOMIO TAKEUCHI, HAMAO UMEZAWA

Author information

ROKURO OKAMOTO
Central Research Laboratories, Sanraku Ocean Co., Ltd.
MASAMI TSUCHIYA
Central Research Laboratories, Sanraku Ocean Co., Ltd.
HIDEO NOMURA
Central Research Laboratories, Sanraku Ocean Co., Ltd.
HIROSHI IGUCHI
Central Research Laboratories, Sanraku Ocean Co., Ltd.
KOHKI KIYOSHIMA
Central Research Laboratories, Sanraku Ocean Co., Ltd.
SENJI HORI
Central Research Laboratories, Sanraku Ocean Co., Ltd.
TAIJI INUI
Central Research Laboratories, Sanraku Ocean Co., Ltd.
TSUTOMU SAWA
Institute of Microbial Chemistry
TOMIO TAKEUCHI
Institute of Microbial Chemistry
HAMAO UMEZAWA
Institute of Microbial Chemistry

JOURNAL FREE ACCESS

1980 Volume 33 Issue 11 Pages 1309-1315

DOI https://doi.org/10.7164/antibiotics.33.1309

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Abstract

The antibacterial activity of acyl derivatives of tylosin were examined in vitro and in vitro. The 4''-acyl group in the acylated tylosins enhanced the antibacterial activity and antimycoplasmal activity against some macrolide-resistant strains. The orally administered 3-acetyl-4''-isovaleryltylosin produced a higher blood level in mice and rabbits than tylosin and a good therapeutic effect on the infection of Staphylococcus aureus Smith in mice.

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