SYNTHESES OF CORIOLIN, 1-DEOXY-1-KETOCORIOLIN AND 1, 8-DIDEOXY- 1, 8-DIKETOCORIOLIN FROM CORIOLIN B

Abstract

Hydrolysis of 5, 8-di-O-tetrahydropyranyl-5-deoxo-5-hydroxycoriolin which was prepared from coriolin B, followed by oxidation of the hydroxy groups at C-5, or C-1 and C-5, or C-1, C-5 and C-8 afforded coriolin (2), 1-deoxy-1-ketocoriolin (3) and 1, 8-dideoxy-1, 8- diketocoriolin (4). All three ketones were found to have antitumor activity, whereas antibacterial activity was observed in 2 and 3 but not in 4.