The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ANTIBIOTICS FROM BASIDIOMYCETES. X1) SCORODONIN, A NEW ANTIBACTERIAL AND ANTIFUNGAL METABOLITE FROM MARASMIUS SCORODONIUS (FR.) FR.
TIMM ANKEJUTTA KUPKAGEORG SCHRAMMWOLFGANG STEGLICH
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1980 Volume 33 Issue 5 Pages 463-467

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Abstract

Scorodonin (1), a novel biologically active metabolite, was isolated from submerged cultures of the mushroom Marasmius scorodonius (FR.) FR. Its structure has been determined by chemical and physical methods. The antibiotic inhibits the growth of bacteria, yeasts, and filamentous fungi. In cells of the ascitic form of EHRLICH carcinoma the incorporation of thymidine and uridine into DNA and RNA is strongly inhibited by scorodonin whereas the incorporation of leucine into protein is not affected.

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