The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
CHARACTERIZATION OF AROMATIC HEPTAENE MACROLIDE ANTIBIOTICS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
W. MECHLINSKIC. P. SCHAFFNER
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1980 Volume 33 Issue 6 Pages 591-599

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Abstract

High performance liquid chromatographic (HPLC) procedures were utilized for the rapid and efficient separation and characterization of the aromatic heptaene macrolide group of antifungal antibiotics. The instrument utilized a 350nm phosphor converted ultraviolet detector and a μ Bondapak C18 column packing. Optimum resolution of eleven commercial aromatic heptaene macrolide preparations was obtained with solvent systems consisting of mixtures of acetonitrile and 0.05 M aqueous sodium citrate buffer, pH 5.3. The presence of two distinct types of aromatic heptaene macrolides with numerous well-defined individual components has been established.

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© Japan Antibiotics Research Association
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