The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
TETRONIC ACID DERIVATIVES FROM ASPERGILLUS PANAMENSIS
PRODUCTION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY*
H. ANKEH. SCHWABH. ACHENBACH
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1980 Volume 33 Issue 9 Pages 931-939

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Abstract

When Aspergillus pauamensis, CBS 120.45, was grown on a medium with high carbon and low nitrogen content, it was found to produce six antibiotically active metabolites. All compounds were identified as tetronic acid derivatives; three of them were found to be identical with gregatins A, B, and D, previously reported as metabolites of Cephalosporiuin gregatum. The other three compounds are new. All six compounds show antibacterial activity towards Gram-negative and Gram-positive bacteria. Five of the antibiotics exhibit inhibitory effects on the macromolecular syntheses in cells of the ascitic form of EHRLICH carcinoma (ECA) of mice.

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© Japan Antibiotics Research Association
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