STUDIES ON NEPLANOCIN A, NEW ANTITUMOR ANTIBIOTIC. I PRODUCING ORGANISM, ISOLATION AND CHARACTERIZATION

SATOSHI YAGINUMA; NAOKI MUTO; MASATOSHI TSUJINO; YASUHIRO SUDATE; MITSUO HAYASHI; MASARU OTANI

doi:10.7164/antibiotics.34.359

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

STUDIES ON NEPLANOCIN A, NEW ANTITUMOR ANTIBIOTIC. I

PRODUCING ORGANISM, ISOLATION AND CHARACTERIZATION

SATOSHI YAGINUMA, NAOKI MUTO, MASATOSHI TSUJINO, YASUHIRO SUDATE, MITSUO HAYASHI, MASARU OTANI

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JOURNAL FREE ACCESS

1981 Volume 34 Issue 4 Pages 359-366

DOI https://doi.org/10.7164/antibiotics.34.359

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Abstract

Neplanocin A, C₁₁H₁₃N₅O₃, is a novel carbocyclic analog of adenosine with cyclopentene. It was isolated from the culture filtrate of Ampullariella regularis A11079 by means of ion-exchange, carbon, silica gel adsorption, or partition chromatography. Neplanocin A forms crystals, and is stable at acidic or alkaline pH. Neplanocin A has cytotoxicity against L5178Y cells in culture and showed a remarkable effect on the life prolongation of mice infected with L1210 leukemia.

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