CHEMICAL MODIFICATION OF FORTIMICINS

IV. PREPARATION OF 4, 2'-DI-N-SUBSTITUTED FORTIMICIN B DERIVATIVES

Abstract

2-Aminoethyl, glycyl, (S)-4-amino-2-hydroxybutyl and (S)-4-amino-2-hydroxybutyryl groups were introduced to the 2'-amino group of 4-N-[(S)-4-amino-2-hydroxybutyl]fortimicin B (2). All of the derivatives of this type prepared showed antibacterial activity almost as strong as fortimicin A (1) and were also active against fortimicin A resistant bacteria which can inactivate fortimicin A by producing an inactivating enzyme AAC(3)-I.