The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ENZYMATIC ADENYLYLATION OF SPECTINOMYCIN BY ACINETOBACTER CALCOACETICUS SUBSP. ANITRATUS
SHOJI SHIMIZU, MATSUHISA INOUE, SUSUMU MITSUHASHI, HIROSHI NAGANAWA, SHINICHI KONDO
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1981 Volume 34 Issue 7 Pages 869-875

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Abstract
Spectinomycin (SPC) was inactivated in the presence of adenosine-5'-triphosphate and magnesium ion by an enzyme preparation made from Acinetobacter calcoaceticus subsp. anitratus GN12313 resistant to both SPC and streptomycin. The structure of the inactivated SPC was found to be the adenylylated product of the hydroxy group on C-9 of the actinamine moiety.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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