TRANSFORMATION OF RIFAMYCIN S INTO RIFAMYCINS B AND L A REVISION OF THE CURRENT BIOSYNTHETIC HYPOTHESIS

ORESTE GHISALBA; RUTH ROOS; THOMAS SCHUPP; JAKOB NÜESCH

doi:10.7164/antibiotics.35.74

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

TRANSFORMATION OF RIFAMYCIN S INTO RIFAMYCINS B AND L A REVISION OF THE CURRENT BIOSYNTHETIC HYPOTHESIS

ORESTE GHISALBA, RUTH ROOS, THOMAS SCHUPP, JAKOB NÜESCH

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JOURNAL FREE ACCESS

1982 Volume 35 Issue 1 Pages 74-80

DOI https://doi.org/10.7164/antibiotics.35.74

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Abstract

The transformation of rifamycin S into rifamycins B and L was reinvestigated in order to establish more detailed pathways. Our results exclude rifamycin O as a common progenitor in the biosyntheses of rifamycins B and L. Rifamycins B and L are formed from rifamycin S (SV) by different pathways using different C3-precursors for the biosynthesis of their glycolic acid moieties. A thiamine-dependent enzyme (decarboxylase) seems to be involved in the transformation reaction.

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