The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SYNTHESIS OF FORPHENICINOL AND FORPHENICINE
HAJIME MORISHIMA, JUNJI YOSHIZAWA, RYOSUKE USHIJIMA, TOMIO TAKEUCHI, HAMAO UMEZAWA
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1982 Volume 35 Issue 11 Pages 1500-1506

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Abstract

Forphenicinol, L-2-(3-hydroxy-4-hydroxymethylphenyl)glycine, was synthesized by two methods starting from dimethyl hydroxyterephthalate or DL-2-(3-hydroxyphenyl)glycine. Forphenicine, L-2-(4-formyl-3-hydroxyphenyl)glycine, was prepared from L-forphenicinol by oxidation, thus establishing configuration of forphenicine to be L. D-Forphenicinol was determined to be biologically inactive.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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