CADEGUOMYCIN, A NOVEL NUCLEOSIDE ANALOG ANTIBIOTIC I. THE PRODUCING ORGANISM, PRODUCTION AND ISOLATION OF CADEGUOMYCIN

NOBUO TANAKA; RONG TSUN WU; TAKAYOSHI OKABE; HIDE YAMASHITA; AKIRA SHIMAZU; TOSHIO NISHIMURA

doi:10.7164/antibiotics.35.272

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

CADEGUOMYCIN, A NOVEL NUCLEOSIDE ANALOG ANTIBIOTIC

I. THE PRODUCING ORGANISM, PRODUCTION AND ISOLATION OF CADEGUOMYCIN

NOBUO TANAKA, RONG TSUN WU, TAKAYOSHI OKABE, HIDE YAMASHITA, AKIRA SHIMAZU, TOSHIO NISHIMURA

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JOURNAL FREE ACCESS

1982 Volume 35 Issue 3 Pages 272-278

DOI https://doi.org/10.7164/antibiotics.35.272

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Abstract

An actinomycete strain IM7912T was found to produce cadeguomycin, a new nucleoside analog antibiotic, together with tubercidin. Morphological, cultural and physiological studies showed that the organism belongs to the species Streptomyces hygroscopicus. Comparisons with S. hygroscopicus ISP 5578 revealed that both strains possess similar characteristics except for production of yellow or brownish yellow soluble pigment in some media. Cadeguomycin was isolated from the culture filtrate, separated from tubercidin, and purified.

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