C-19393 E₅, A NEW CARBAPENEM ANTIBIOTIC FERMENTATION, ISOLATION AND STRUCTURE

Abstract

A new carbapenem antibiotic, C-19393 E₅, was isolated from the culture filtrate of Streptomyces griseus subsp. cryophilus C-19393 as a minor component. The chemical structure of the antibiotic was determined by comparing its spectral data with those of the known 5, 6-cis carbapenem antibiotics and confirmed by partial synthesis from epithienamycin B as shown in Fig. 1.The antibiotic has a broad antimicrobial spectrum and shows strong inhibitory activity againstβ-lactamases.