TETROCARCINS E₁, E₂, F AND F-1, NEW ANTIBIOTICS FERMENTATION, ISOLATION AND CHARACTERIZATION

Abstract

New components of tetrocarcins (E₁, E₂, F and F-1) were found in the culture broth of Micromonospora chalcea KY 11091 that was known to produce tetrocarcins A, B and C Tetrocarcin F-1 consisted of tetronolide and nitro sugar (tetronitrose). Tetrocarcins E₁ and E₂ consisted of F-1 and deoxy sugar (L-digitoxose). Tetrocarcin F consisted of F-1 and two deoxy sugars (their structures were not yet determined). They all showed antibacterial activities against Gram-positive bacteria and the specific activity decreased with decrease in the numbers of deoxy sugars attached to the aglycone.