NOVEL RIFAMYCINS. III SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 3-AMIDINO- AND OF 4-AMINOIMIDAZOLO[4, 5-c]RIFAMYCIN DERIVATIVES

LEONARDO MARSILI; GIOVANNI FRANCESCHI; MARZIA BALLABIO; GIULIANO ORONZO; ARISTIDE VIGEVANI; DOMENICO UNGHERI; COSTANTINO DELLA BRUNA; AURORA SANFILIPPO

doi:10.7164/antibiotics.36.1495

NOVEL RIFAMYCINS. III

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 3-AMIDINO- AND OF 4-AMINOIMIDAZOLO[4, 5-c]RIFAMYCIN DERIVATIVES

LEONARDO MARSILI, GIOVANNI FRANCESCHI, MARZIA BALLABIO, GIULIANO ORONZO, ARISTIDE VIGEVANI, DOMENICO UNGHERI, COSTANTINO DELLA BRUNA, AURORA SANFILIPPO

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JOURNAL FREE ACCESS

1983 Volume 36 Issue 11 Pages 1495-1501

DOI https://doi.org/10.7164/antibiotics.36.1495

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Abstract

A number of semisynthetic rifamycin derivatives modified at position 3 and/or 4, belonging to general structures 2 and 4 (see Scheme 1), have been obtained. The synthesis and the biological activities of the new compounds are described. Compounds 4p and 4qGS display very good antimycobacterial activity in mice.

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