The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Bu-2470, A NEW PEPTIDE ANTIBIOTIC COMPLEX
I. PRODUCTION, ISOLATION AND PROPERTIES OF Bu-2470 A, B1 AND B2
MASATAKA KONISHIKOKO SUGAWARAKOJI TOMITAKIYOSHI MATSUMOTOTAKEO MIYAKIKEI-ICHI FUJISAWAHIROSHI TSUKIURAHIROSHI KAWAGUCHI
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1983 Volume 36 Issue 6 Pages 625-633

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Abstract

A strain of Bacillus circulans produced a complex of basic peptide antibiotics designated Bu-2470, which was found to contain four active components, A, B1, B2a and B2b. Bu-2470 A specifically inhibited various Pseudomonas species including P. aeruginosa, P. maltophilia and P. putida, but otherwise its antibacterial spectrum was limited to certain Gram-negative organisms. Bu-2470 B1 and B2 (B2a+B2b) showed broad antibiotic activity against Gram-positive and Gram-negative bacteria including Pseudomonas species. The physicochemical and biological properties of Bu-2470 B1 and B2 are very similar to those of the octapeptin group of antibiotics.

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© Japan Antibiotics Research Association
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