Bu-2470, A NEW PEPTIDE ANTIBIOTIC COMPLEX

I. PRODUCTION, ISOLATION AND PROPERTIES OF Bu-2470 A, B₁ AND B₂

Abstract

A strain of Bacillus circulans produced a complex of basic peptide antibiotics designated Bu-2470, which was found to contain four active components, A, B₁, B_2a and B_2b. Bu-2470 A specifically inhibited various Pseudomonas species including P. aeruginosa, P. maltophilia and P. putida, but otherwise its antibacterial spectrum was limited to certain Gram-negative organisms. Bu-2470 B₁ and B₂ (B_2a+B_2b) showed broad antibiotic activity against Gram-positive and Gram-negative bacteria including Pseudomonas species. The physicochemical and biological properties of Bu-2470 B₁ and B₂ are very similar to those of the octapeptin group of antibiotics.