METABOLITES OF MICROORGANISMS. 229 ABSOLUTE CONFIGURATION OF NAPHTHOMYCIN A DETERMINED BY X-RAY ANALYSIS AND CHEMICAL DEGRADATION

WALTER KELLER-SCHIERLEIN; MICHAEL MEYER; LUCIANO CELLAI; SILVIO CERRINI; DORIANO LAMBA; ANNALAURA SEGRE; WALTER FEDELI; MARIO BRUFANI

doi:10.7164/antibiotics.37.1357

METABOLITES OF MICROORGANISMS. 229

ABSOLUTE CONFIGURATION OF NAPHTHOMYCIN A DETERMINED BY X-RAY ANALYSIS AND CHEMICAL DEGRADATION

WALTER KELLER-SCHIERLEIN, MICHAEL MEYER, LUCIANO CELLAI, SILVIO CERRINI, DORIANO LAMBA, ANNALAURA SEGRE, WALTER FEDELI, MARIO BRUFANI

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JOURNAL FREE ACCESS

1984 Volume 37 Issue 11 Pages 1357-1361

DOI https://doi.org/10.7164/antibiotics.37.1357

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Abstract

The relative and absolute configurations of naphthomycin A were elucidated by an X-ray structural analysis of a methylation product, 25-O-methylnaphthomycin A iminomethyl ether. The absolute configuratlon was confirmed by degradation(O₃, NaBH₄)to(S)-butane-1, 2, 4-triol.

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