SPENOLIMYCIN, A NEW SPECTINOMYCIN-TYPE ANTIBIOTIC I. DISCOVERY, TAXONOMY AND FERMENTATION

JAMES P. KARWOWSKI; MARIANNA JACKSON; THOMAS A. BOBIK; JOSEPH F. PROKOP; ROBERT J. THERIAULT

doi:10.7164/antibiotics.37.1513

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

SPENOLIMYCIN, A NEW SPECTINOMYCIN-TYPE ANTIBIOTIC

I. DISCOVERY, TAXONOMY AND FERMENTATION

JAMES P. KARWOWSKI, MARIANNA JACKSON, THOMAS A. BOBIK, JOSEPH F. PROKOP, ROBERT J. THERIAULT

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1984 Volume 37 Issue 12 Pages 1513-1518

DOI https://doi.org/10.7164/antibiotics.37.1513

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Abstract

Spenolimycin, a new spectinomycin-type antibiotic, was discovered in the fermentation broth of a new actinomycete named Streptomyces gilvospiralis sp. nov. strain AB634D-177. Although a small amount of spectinomycin is coproduced by strain AB634D-177, the culture is different from other known spectinomycin-producing actinomycetes. Spenolimycin was obtained by conventional submerged culture in 14-liter fermentors with a peak antibiotic titer of 140 μg/ml.

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