1984 Volume 37 Issue 12 Pages 1579-1586
A new aminosugar named nojirimycin B (1) has been isolated as its bisulfite adduct from the culture broth of Streptomyces lavendulae SF-425, together with nojirimycin. Microbiological oxidation of 1 with Gluconobacter suboxydans IAM 1829 gave a δ-lactam (2). The structures of 1and 2 were determined to be 5-amino-5-deoxy-D-mannopyranose and D-mannonic-δ-lactam, respectively, on the basis of 1H NMR spectroscopy and X-ray structural analysis. Both 1 and2 exhibited powerful inhibitory activity against rat epididymal α-mannosidase and apricot β-glucosidase.