EMPEDOPEPTIN (BMY-28117), A NEW DEPSIPEPTIDE ANTIBIOTIC I. PRODUCTION, ISOLATION AND PROPERTIES

MASATAKA KONISHI; KOKO SUGAWARA; MINORU HANADA; KOJI TOMITA; KOZO TOMATSU; TAKEO MIYAKI; HIROSHI KAWAGUCHI; R. E. BUCK; C. MORE; V. Z. ROSSOMANO

doi:10.7164/antibiotics.37.949

EMPEDOPEPTIN (BMY-28117), A NEW DEPSIPEPTIDE ANTIBIOTIC

I. PRODUCTION, ISOLATION AND PROPERTIES

MASATAKA KONISHI, KOKO SUGAWARA, MINORU HANADA, KOJI TOMITA, KOZO TOMATSU, TAKEO MIYAKI, HIROSHI KAWAGUCHI, R. E. BUCK, C. MORE, V. Z. ROSSOMANO

Author information

MASATAKA KONISHI
Tokyo Research Center, Bristol-Myers Research Institute, Ltd.
KOKO SUGAWARA
Tokyo Research Center, Bristol-Myers Research Institute, Ltd.
MINORU HANADA
Tokyo Research Center, Bristol-Myers Research Institute, Ltd.
KOJI TOMITA
Tokyo Research Center, Bristol-Myers Research Institute, Ltd.
KOZO TOMATSU
Tokyo Research Center, Bristol-Myers Research Institute, Ltd.
TAKEO MIYAKI
Tokyo Research Center, Bristol-Myers Research Institute, Ltd.
HIROSHI KAWAGUCHI
Tokyo Research Center, Bristol-Myers Research Institute, Ltd.
R. E. BUCK
Pharmaceutical Research & Development Division, Bristol-Myers Company
C. MORE
Pharmaceutical Research & Development Division, Bristol-Myers Company
V. Z. ROSSOMANO
Pharmaceutical Research & Development Division, Bristol-Myers Company

JOURNAL FREE ACCESS

1984 Volume 37 Issue 9 Pages 949-957

DOI https://doi.org/10.7164/antibiotics.37.949

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Abstract

Empedopeptin is a new antibiotic produced by Empedobacter haloabium nov. sp. (ATCC 31962). It is a water-soluble depsipeptide antibiotic containing eight amino acid residues and a C₁₄-fatty acid moiety in the molecule. Although structurally unrelated, empedopeptin and vancomycin have similar antimicrobial spectra against aerobic and anaerobic Gram-positive bacteria including antibiotic-resistant strains. Empedopeptin is highly active in vivo in mice against systemic infections of Staphylococcus aureus, Streptococcus pyogenes and Clostridium perfringens. Empedopeptin is not absorbed orally.

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