LACTOQUINOMYCIN, A NOVEL ANTICANCER ANTIBIOTIC II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ASSIGNMENT

TAKAYOSHI OKABE; KUNIKO NOMOTO; HIROSHI FUNABASHI; SHIGENOBU OKUDA; HIDEO SUZUKI; NOBUO TANAKA

doi:10.7164/antibiotics.38.1333

LACTOQUINOMYCIN, A NOVEL ANTICANCER ANTIBIOTIC

II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ASSIGNMENT

TAKAYOSHI OKABE, KUNIKO NOMOTO, HIROSHI FUNABASHI, SHIGENOBU OKUDA, HIDEO SUZUKI, NOBUO TANAKA

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JOURNAL FREE ACCESS

1985 Volume 38 Issue 10 Pages 1333-1336

DOI https://doi.org/10.7164/antibiotics.38.1333

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Abstract

Lactoquinomycin, a new antibiotic, C₂₄H₂₇NO₈, mp 151-159°C (dec), FAB-MS: m/z 458 (MH⁺), is a basic substance, showing UV λ^MeOH_max (ε) 215 (37, 600), 254 (10, 700) and 432nm (4, 760), and IR νCHCl₃_max (γ-lactone), 1665 and 1650 (quinone) cm^-1. The structure of lactoquinomycin has been elucidated by ^-1H NMR and ORD in comparison with those of kalafungin.

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