STUDIES ON WB-3559 A, B, C AND D, NEW POTENT FIBRINOLYTIC AGENTS I. DISCOVERY, IDENTIFICATION, ISOLATION AND CHARACTERIZATION

KEIZO YOSHIDA; MORITA IWAMI; YOSHIKAZU UMEHARA; MOTOAKI NISHIKAWA; ITSUO UCHIDA; MASANOBU KOHSAKA; HATSUO AOKI; HIROSHI IMANAKA

doi:10.7164/antibiotics.38.1469

STUDIES ON WB-3559 A, B, C AND D, NEW POTENT FIBRINOLYTIC AGENTS

I. DISCOVERY, IDENTIFICATION, ISOLATION AND CHARACTERIZATION

KEIZO YOSHIDA, MORITA IWAMI, YOSHIKAZU UMEHARA, MOTOAKI NISHIKAWA, ITSUO UCHIDA, MASANOBU KOHSAKA, HATSUO AOKI, HIROSHI IMANAKA

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JOURNAL FREE ACCESS

1985 Volume 38 Issue 11 Pages 1469-1475

DOI https://doi.org/10.7164/antibiotics.38.1469

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Abstract

WB-3559 A, B, C and D were produced by a bacterium which was classified as a member of the genus Flavobacterium. These compounds were purified by solvent extraction followed by chromatography on silica gel and then isolated by HPLC. The chemical structures were determined on the basis of chemical and spectroscopic evidence as in the succeeding papers. WB-3559 A, B, C and D stimulated rabbit plasma euglobulin clot lysis time. A chemically synthesized compound (WB-3559 D-syn) stimulated mouse plasma euglobulin clot lysis time when injected intravenously.

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