ENHANCEMENT OF ANTITUMOR EFFECT OF CYTOTOXIC AGENTS BY BESTATIN

FUMINORI ABE; KYOICHI SHIBUYA; JUNKO ASHIZAWA; KATSUTOSHI TAKAHASHI; HIROO HORINISHI; AKIRA MATSUDA; MASAAKI ISHIZUKA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.38.411

FUMINORI ABE, KYOICHI SHIBUYA, JUNKO ASHIZAWA, KATSUTOSHI TAKAHASHI, HIROO HORINISHI, AKIRA MATSUDA, MASAAKI ISHIZUKA, TOMIO TAKEUCHI, HAMAO UMEZAWA

Author information

FUMINORI ABE
Research Laboratories, Pharmaceutical Division, Nippon Kayaku Co., Ltd.
KYOICHI SHIBUYA
Research Laboratories, Pharmaceutical Division, Nippon Kayaku Co., Ltd.
JUNKO ASHIZAWA
Research Laboratories, Pharmaceutical Division, Nippon Kayaku Co., Ltd.
KATSUTOSHI TAKAHASHI
Research Laboratories, Pharmaceutical Division, Nippon Kayaku Co., Ltd.
HIROO HORINISHI
Research Laboratories, Pharmaceutical Division, Nippon Kayaku Co., Ltd.
AKIRA MATSUDA
Research Laboratories, Pharmaceutical Division, Nippon Kayaku Co., Ltd.
MASAAKI ISHIZUKA
Institute of Microbial Chemistry
TOMIO TAKEUCHI
Institute of Microbial Chemistry
HAMAO UMEZAWA
Institute of Microbial Chemistry

JOURNAL FREE ACCESS

1985 Volume 38 Issue 3 Pages 411-414

DOI https://doi.org/10.7164/antibiotics.38.411

Details

Abstract

Bestatin enhanced the antitumor effects of mitomycin C, 5-fluorouracil and cis-dichlorodiammineplatinum against a syngeneic solid tumor of colon adenocarcinoma 26 in BALB/c mice. The enhancement was dependent on administration schedule. Bestatin administration after treatment with the cytotoxic agents was more effective than that made before the treatment.

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