GRISEOLIC ACID, AN INHIBITOR OF CYCLIC ADENOSINE 3', 5'-MONOPHOSPHATE PHOSPHODIESTERASE II. THE STRUCTURE OF GRISEOLIC ACID

SHUJI TAKAHASHI; FUMIO NAKAGAWA; KAYOKO KAWAZOE; YOJI FURUKAWA; SADAO SATO; CHIHIRO TAMURA; ATSUSHI NAITO

doi:10.7164/antibiotics.38.830

GRISEOLIC ACID, AN INHIBITOR OF CYCLIC ADENOSINE 3', 5'-MONOPHOSPHATE PHOSPHODIESTERASE

II. THE STRUCTURE OF GRISEOLIC ACID

SHUJI TAKAHASHI, FUMIO NAKAGAWA, KAYOKO KAWAZOE, YOJI FURUKAWA, SADAO SATO, CHIHIRO TAMURA, ATSUSHI NAITO

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JOURNAL FREE ACCESS

1985 Volume 38 Issue 7 Pages 830-834

DOI https://doi.org/10.7164/antibiotics.38.830

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Abstract

Griseolic acid, a potent inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase, was isolated from the fermentation broth of Streptomyces griseoaurantiacus SANK 63479. Treatment of griseolic acid with HCl-MeOH gave adenine and pseudo-sugar. The structure of griseolic acid, adenine nucleoside type structure, was elucidated by chemical degradation and X-ray analysis, and was shown to be structure 1.

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