ANGIOTENSIN CONVERTING ENZYME INHIBITORS PRODUCED BY STREPTOMYCES CHROMOFUSCUS

DISCOVERY, TAXONOMY AND FERMENTATION

Abstract

Culture A58365.1, NRRL 15098, identified as a new strain of Streptomyces chromofuscus, was found to produce two novel angiotensin converting enzyme (ACE) inhibitors, A58365A and A58365B. Fermentation medium studies afforded an increase in ACE inhibitor titers from less than 1 μg/ml to greater than 20 μg/ml. Proline was the obligatory supplement for ACE inhibitor biosynthesis.