STUDIES ON MONOCYCLIC β-LACTAM ANTIBIOTICS III. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF <i>N</i>-(AROMATIC HETEROCYCLIC SU BSTITUTED)AZETIDIN-2-ONES

CHOSAKU YOSHIDA; KIYOSHI TANAKA; JOJI NAKANO; YOZO TODD; TETSUO YAMAFUJI; RIKIZO HATTORI; YOSHIKAZU FUKUOKA; ISAMU SAIKAWA

doi:10.7164/antibiotics.39.76

STUDIES ON MONOCYCLIC β-LACTAM ANTIBIOTICS

III. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-(AROMATIC HETEROCYCLIC SU BSTITUTED)AZETIDIN-2-ONES

CHOSAKU YOSHIDA, KIYOSHI TANAKA, JOJI NAKANO, YOZO TODD, TETSUO YAMAFUJI, RIKIZO HATTORI, YOSHIKAZU FUKUOKA, ISAMU SAIKAWA

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 1 Pages 76-89

DOI https://doi.org/10.7164/antibiotics.39.76

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Abstract

The relationship between structure and antibacterial activity among monocyclic β-lactams having a pyridyl, pyrimidinyl, thiazolyl, imidazolyl, or a tetrazolyl group at N-1 position was investigated. N-(Tetrazol-5-yl)azetidin-2-ones were found to posses excellent activity.

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