KIBDELINS, NOVEL GLYCOPEPTIDE ANTIBIOTICS I. DISCOVERY, PRODUCTION, AND BIOLOGICAL EVALUATION

M. C. SHEARER; A. J. GIOVENELLA; S. F. GRAPPEL; R. D. HEDDE; R. J. MEHTA; Y. K. OH; C. H. PAN; D. H. PITKIN; L. J. NISBET

doi:10.7164/antibiotics.39.1386

KIBDELINS, NOVEL GLYCOPEPTIDE ANTIBIOTICS

I. DISCOVERY, PRODUCTION, AND BIOLOGICAL EVALUATION

M. C. SHEARER, A. J. GIOVENELLA, S. F. GRAPPEL, R. D. HEDDE, R. J. MEHTA, Y. K. OH, C. H. PAN, D. H. PITKIN, L. J. NISBET

Author information

M. C. SHEARER
Research and Development Division, Smith Kline & French Laboratories
A. J. GIOVENELLA
Research and Development Division, Smith Kline & French Laboratories
S. F. GRAPPEL
Research and Development Division, Smith Kline & French Laboratories
R. D. HEDDE
Research and Development Division, Smith Kline & French Laboratories
R. J. MEHTA
Research and Development Division, Smith Kline & French Laboratories
Y. K. OH
Research and Development Division, Smith Kline & French Laboratories
C. H. PAN
Research and Development Division, Smith Kline & French Laboratories
D. H. PITKIN
Research and Development Division, Smith Kline & French Laboratories
L. J. NISBET

JOURNAL FREE ACCESS

1986 Volume 39 Issue 10 Pages 1386-1394

DOI https://doi.org/10.7164/antibiotics.39.1386

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Abstract

A new subspecies of Kibdelosporangium aridum subsp. largum (SK&F AAD-609), was isolated and shown to produce novel glycopeptides related to aridicins, but containing a homologous series of glycolipids based on N-acylglucosamine. These compounds showed improvements over the aridicins in in vitro activity and were effective in mouse protection studies against a range of Gram-positive bacteria, including methicillin resistant staphylococci. Pharmacokinetic studies indicated that they have high serum concentrations and long-acting potential. The kibdelin complex modified rumen metabolism in a manner favorable for growth promotion.

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