IZUPEPTINS A AND B, NEW GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY AN ACTINOMYCETE

PRISKA SPIRI-NAKAGAWA; YUKIKO FUKUSHI; KAZUNORI MAEBASHI; NOBUTAKA IMAMURA; YOKO TAKAHASHI; YOSHITAKE TANAKA; HARUO TANAKA; SATOSHI OMURA

doi:10.7164/antibiotics.39.1719

PRISKA SPIRI-NAKAGAWA, YUKIKO FUKUSHI, KAZUNORI MAEBASHI, NOBUTAKA IMAMURA, YOKO TAKAHASHI, YOSHITAKE TANAKA, HARUO TANAKA, SATOSHI OMURA

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PRISKA SPIRI-NAKAGAWA
The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
YUKIKO FUKUSHI
The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
KAZUNORI MAEBASHI
The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
NOBUTAKA IMAMURA
The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
YOKO TAKAHASHI
The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
YOSHITAKE TANAKA
The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
HARUO TANAKA
The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
SATOSHI OMURA
The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University

JOURNAL FREE ACCESS

1986 Volume 39 Issue 12 Pages 1719-1723

DOI https://doi.org/10.7164/antibiotics.39.1719

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Abstract

In the course of screening for new high molecular weight peptidoglycan synthesis inhibitors, izupeptins A and B, antibiotics active against Gram-positive bacteria including methicillin-resistant Staphylococci and Clostridium were discovered. The antibiotics were found to be new members of the glycopeptide antibiotic family, namely of the vancomycin type, based on chemical and spectroscopic data. The molecular weight of izupeptin A was determined to be 1, 475 by SI (secondary ion)-MS (integer molecular weight, 1, 473), and it contains two chlorine atoms.

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