The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
AMINOGLYCOSIDE ANTIBIOTICS
7. DIHYDROSTREPTOMYCIN ANALOGUES
DANA L. DELAWARE, MAHENDRA S. SHARMA, BHASHYAM S. IYENGAR, WILLIAM A. REMERS, TERESA A. PURSIANO
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1986 Volume 39 Issue 2 Pages 251-258

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Abstract
Dihydrostreptomycin analogues with structural variations in their guanidino groups were prepared. The analogue with a methyl group on the guanidine at C-1 was nearly as active as dihydrostreptomycin against bacteria. However, the 2-imidazolin-2-ylamino substituent at C-1 eliminated activity. No analogue with a substituent on the C-3 guanidino group was active.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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