The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
CRISAMICIN A, A NEW ANTIBIOTIC FROM MICROMONOSPORA
I. TAXONOMY OF THE PRODUCING STRAIN, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL CHARACTERIZATION AND ANTIMICROBIAL PROPERTIES
RICHARD A. NELSONJOSEPH A. POPE Jr.GEORGE M. LUEDEMANNLLOYD E. MCDANIELCARL P. SCHAFFNER
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1986 Volume 39 Issue 3 Pages 335-344

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Abstract

A microorganism, designated as RV-79-9-101 and now identified as Micromonospora purpureochromogenes subsp. halotolerans, isolated from a mud sample in the Philippines, has been shown to produce a complex of antibiotics called crisamicins. Thin-layer chromatography and bioautography, employing solvent extracts of whole fermentation broths, revealed a minimum of five antimicrobial components. The major biologically-active component
of the antibiotic complex, crisamicin A, was obtained in pure form after preparative silica gel column chromatography followed by crystallization. Based on physico-chemical data crisamicin A has been identified as a novel member of the isochromanequinone group of antibiotics. It exhibits excellent in vitro activity against Gram-positive bacteria but little or no activity towards Gram-negative bacteria or fungi.

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© Japan Antibiotics Research Association
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