NOVEL ANTIBIOTICS NAPYRADIOMYCINS PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

KAZURO SHIOMI; HIRONOBU IINUMA; MASA HAMADA; HIROSHI NAGANAWA; MAYUMI MANABE; CHIEKO MATSUKI; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.39.487

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

NOVEL ANTIBIOTICS NAPYRADIOMYCINS PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

KAZURO SHIOMI, HIRONOBU IINUMA, MASA HAMADA, HIROSHI NAGANAWA, MAYUMI MANABE, CHIEKO MATSUKI, TOMIO TAKEUCHI, HAMAO UMEZAWA

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1986 Volume 39 Issue 4 Pages 487-493

DOI https://doi.org/10.7164/antibiotics.39.487

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Abstract

Novel antibacterial antibiotics napyradiomycins A, A1, B2, B3, C1 and C2 have been isolated from the culture broth of Chainia rubra MGS02-AFI. In this paper, taxonomy of the producer, and production, isolation, physico-chemical properties and biological activities of napyradiomycins are reported. They contain the naphtopyran chromophore and halogens, and inhibit the growth of Gram-positive bacteria including drug-resistant strains.

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