CLAVAMYCINS, NEW CLAVAM ANTIBIOTICS FROM TWO VARIANTS OF STREPTOMYCES HYGROSCOPICUS

II. ISOLATION AND STRUCTURES OF CLAVAMYCINS A, B AND C FROM STREPTOMYCES HYGROSCOPICUS NRRL 15846, AND OF CLAVAMYCINS D, E AND F FROM STREPTOMYCES HYGROSCOPICUS NRRL 15879

Abstract

Clavamycins A, B, C, D, E and F represent new members of the clavam antibiotics group. Their purification was achieved by a variety of preparative chromatographic methods, essentially on reversed phase carrier. The structures were deduced from spectroscopic properties, especially from extensive NMR studies.