PLIPASTATINS: NEW INHIBITORS OF PHOSPHOLIPASE A2, PRODUCED BY BACILLUS CEREUS BMG302-fF67 III. STRUCTURAL ELUCIDATION OF PLIPASTATINS

TAKAAKI NISHIKIORI; HIROSHI NAGANAWA; YASUHIKO MURAOKA; TAKAAKI AOYAGI; HAMAO UMEZAWA

doi:10.7164/antibiotics.39.755

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

PLIPASTATINS: NEW INHIBITORS OF PHOSPHOLIPASE A2, PRODUCED BY BACILLUS CEREUS BMG302-fF67

III. STRUCTURAL ELUCIDATION OF PLIPASTATINS

TAKAAKI NISHIKIORI, HIROSHI NAGANAWA, YASUHIKO MURAOKA, TAKAAKI AOYAGI, HAMAO UMEZAWA

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1986 Volume 39 Issue 6 Pages 755-761

DOI https://doi.org/10.7164/antibiotics.39.755

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Abstract

Plipastatins are new inhibitors of phospholipase A2 produced by Bacillus cereus BMG302-fF67. Structures of the plipastatins have been determined by UV, mass and NMR spectrometries and chemical degradation. The carboxyl group of the C-terminal L-isoleucine of plipastatinic acid has been shown to form a lactone linkage with the hydroxyl group of Ltyrosine. The total structure of plipastatins has thus been established.

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