PD 116, 152, A NEW PHENAZINE ANTITUMOR ANTIBIOTIC STRUCTURE AND ANTITUMOR ACTIVITY

T. A. SMITKA; R. H. BUNGE; J. H. WILTON; G. C. HOKANSON; J. C. FRENCH; HE CUN-HENG; JON CLARDY

doi:10.7164/antibiotics.39.800

PD 116, 152, A NEW PHENAZINE ANTITUMOR ANTIBIOTIC

STRUCTURE AND ANTITUMOR ACTIVITY

T. A. SMITKA, R. H. BUNGE, J. H. WILTON, G. C. HOKANSON, J. C. FRENCH, HE CUN-HENG, JON CLARDY

Author information

JOURNAL FREE ACCESS

1986 Volume 39 Issue 6 Pages 800-803

DOI https://doi.org/10.7164/antibiotics.39.800

Details

Abstract

A new, highly substituted phenazine with antitumor activity was isolated from the culture broth of a Streptomyces sp. This compound, whose structure was determined by spectroscopic methods and verified by X-ray diffraction analysis, was found to be methyl 6-formyl-4, 7, 9-trihydroxy-8-methyl-1-phenazinecarboxylate.

Corresponding author

Register with J-STAGE for free!