The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
INTENSELY POTENT ANTHRACYCLINE ANTIBIOTIC OXAUNOMYCIN PRODUCED BY A BLOCKED MUTANT OF THE DAUNORUBICIN-PRODUCING MICROORGANISM
AKIHIRO YOSHIMOTOSHIZUKA FUJIIOSAMU JOHDOKATSURO KUBOTOMOYUKI ISHIKURAHIROSHI NAGANAWATSUTOMU SAWATOMIO TAKEUCHIHAMAO UMEZAWA
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1986 Volume 39 Issue 7 Pages 902-909

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Abstract

A new potent anthracycline antibiotic oxaunomycin was isolated from the culture broth of a blocked mutant derived from a baumycin producer and was identified as 7-O-(α-L-daunosaminyl)-β-rhodomycinone. It exhibited about 100 times more strongly cytotoxic activity against leukemic L1210 cell culture than doxorubicin.

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