INTENSELY POTENT ANTHRACYCLINE ANTIBIOTIC OXAUNOMYCIN PRODUCED BY A BLOCKED MUTANT OF THE DAUNORUBICIN-PRODUCING MICROORGANISM

AKIHIRO YOSHIMOTO; SHIZUKA FUJII; OSAMU JOHDO; KATSURO KUBO; TOMOYUKI ISHIKURA; HIROSHI NAGANAWA; TSUTOMU SAWA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.39.902

AKIHIRO YOSHIMOTO, SHIZUKA FUJII, OSAMU JOHDO, KATSURO KUBO, TOMOYUKI ISHIKURA, HIROSHI NAGANAWA, TSUTOMU SAWA, TOMIO TAKEUCHI, HAMAO UMEZAWA

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 7 Pages 902-909

DOI https://doi.org/10.7164/antibiotics.39.902

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Abstract

A new potent anthracycline antibiotic oxaunomycin was isolated from the culture broth of a blocked mutant derived from a baumycin producer and was identified as 7-O-(α-L-daunosaminyl)-β-rhodomycinone. It exhibited about 100 times more strongly cytotoxic activity against leukemic L1210 cell culture than doxorubicin.

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