CEFODIZIME, AN AMINOTHIAZOLYLCEPHALOSPORIN V. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS IN THE CEFODIZIME SERIES

JÜRGEN BLUMBACH; WALTER DÜRCKHEIMER; EBERHARD EHLERS; KLAUS FLEISCHMANN; NORBERT KLESEL; MICHAEL LIMBERT; BURKHARD MENCKE; JÜRGEN REDEN; KARL H. SCHEUNEMANN; ELMAR SCHRINNER; GERHARD SEIBERT; MANFRED WIEDUWILT; MANFRED WORM

doi:10.7164/antibiotics.40.29

CEFODIZIME, AN AMINOTHIAZOLYLCEPHALOSPORIN

V. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS IN THE CEFODIZIME SERIES

JÜRGEN BLUMBACH, WALTER DÜRCKHEIMER, EBERHARD EHLERS, KLAUS FLEISCHMANN, NORBERT KLESEL, MICHAEL LIMBERT, BURKHARD MENCKE, JÜRGEN REDEN, KARL H. SCHEUNEMANN, ELMAR SCHRINNER, GERHARD SEIBERT, MANFRED WIEDUWILT, MANFRED WORM

Author information

JÜRGEN BLUMBACH
Pharma Forschung, Hoechst Aktiengesellschaft
WALTER DÜRCKHEIMER
Pharma Forschung, Hoechst Aktiengesellschaft
EBERHARD EHLERS
Pharma Forschung, Hoechst Aktiengesellschaft
KLAUS FLEISCHMANN
Pharma Forschung, Hoechst Aktiengesellschaft
NORBERT KLESEL
Pharma Forschung, Hoechst Aktiengesellschaft
MICHAEL LIMBERT
Pharma Forschung, Hoechst Aktiengesellschaft
BURKHARD MENCKE
Pharma Forschung, Hoechst Aktiengesellschaft
JÜRGEN REDEN
Pharma Forschung, Hoechst Aktiengesellschaft
KARL H. SCHEUNEMANN
Pharma Forschung, Hoechst Aktiengesellschaft
ELMAR SCHRINNER
Pharma Forschung, Hoechst Aktiengesellschaft
GERHARD SEIBERT
Pharma Forschung, Hoechst Aktiengesellschaft
MANFRED WIEDUWILT
Pharma Forschung, Hoechst Aktiengesellschaft
MANFRED WORM
Pharma Forschung, Hoechst Aktiengesellschaft

JOURNAL FREE ACCESS

1987 Volume 40 Issue 1 Pages 29-42

DOI https://doi.org/10.7164/antibiotics.40.29

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Abstract

The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC in mice and dogs.

Corresponding author

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