BIOLOGICAL EFFECTS OF ACETOMYCIN I. ACTIVITY AGAINST TUMOR CELLS <i>IN VITRO</i> AND <i>IN VIVO</i>

S. W. MAMBER; J. D. MITULSKI; K. L. HAMELEHLE; J. C. FRENCH; G. C. HOKANSON; J. L. SHILLIS; W. R. LEOPOLD; D. D. VON HOFF; J. B. TUNAC

doi:10.7164/antibiotics.40.73

BIOLOGICAL EFFECTS OF ACETOMYCIN

I. ACTIVITY AGAINST TUMOR CELLS IN VITRO AND IN VIVO

S. W. MAMBER, J. D. MITULSKI, K. L. HAMELEHLE, J. C. FRENCH, G. C. HOKANSON, J. L. SHILLIS, W. R. LEOPOLD, D. D. VON HOFF, J. B. TUNAC

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JOURNAL FREE ACCESS

1987 Volume 40 Issue 1 Pages 73-76

DOI https://doi.org/10.7164/antibiotics.40.73

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Abstract

The antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC₅₀, 1.5μg/ml) and L1210 murine leukemia cells (IC₅₀, 2.2μg/ml). Acetomycin also had marked activity in the human tumor stem cell assay, with a 33% overall response rate (<30% survival) against 49 primary tumors. However, acetomycin was inactive in four in vivo tumor assay systems (L1210 and P388 leukemias, B16 melanoma and the MX-1 mammary xenograft system). This lack of in vitro activity may result from metabolic inactivation of acetomycin.

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