The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
HYGROMYCIN A, AN ANTITREPONEMAL SUBSTANCE
II. THERAPEUTIC EFFECT FOR SWINE DYSENTERY
AKIRA NAKAGAWATOMOKO FUJIMOTOSATOSHI OMURAJAMES C. WALSHRONALD L. STOTISHBEVERLY GEORGE
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1987 Volume 40 Issue 11 Pages 1627-1635

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Abstract

This study was conducted to evaluate hygromycin A fed to growing swine at 1, 5, 10 or 20 g/ton feed for the control of Treponema hyodysenteriae-causGd dysentery. Pigs provided carbadox at 50 g/ton feed served as an infected treatment control group. All pigs were orally, via stomach intubation, administered 100ml of a T. hyodysenteriae broth culture. During the in vivo test, rectal swabs were taken for T. hyodysenteriae isolation, body weights of all pigs and the feed consumption was determined. All pigs were euthanized and necropsied at study end; the large intestine was cultured for T. hyodysenteriae and gross intestinal lesions were noted. T. hyodysenteriae-causQd swine dysentery was successfully controlled by feeding hygromycin A at 5 g/ton. Hygromycin A medicated pigs performed as well as or better than carbadox-medicated pigs.

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© Japan Antibiotics Research Association
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