BISUCABERIN, A NEW SIDEROPHORE, SENSITIZING TUMOR CELLS TO MACROPHAGE-MEDIATED CYTOLYSIS II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

ATSUSHI TAKAHASHI; HIKARU NAKAMURA; TOSHIYUKI KAMEYAMA; SHOGO KURASAWA; HIROSHI NAGANAWA; YOSHIRO OKAMI; TOMIO TAKEUCHI; HAMAO UMEZAWA; YOICHI IITAKA

doi:10.7164/antibiotics.40.1671

BISUCABERIN, A NEW SIDEROPHORE, SENSITIZING TUMOR CELLS TO MACROPHAGE-MEDIATED CYTOLYSIS

II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

ATSUSHI TAKAHASHI, HIKARU NAKAMURA, TOSHIYUKI KAMEYAMA, SHOGO KURASAWA, HIROSHI NAGANAWA, YOSHIRO OKAMI, TOMIO TAKEUCHI, HAMAO UMEZAWA, YOICHI IITAKA

Author information

JOURNAL FREE ACCESS

1987 Volume 40 Issue 12 Pages 1671-1676

DOI https://doi.org/10.7164/antibiotics.40.1671

Details

Abstract

The structure of bisucaberin, a new siderophore, was determined to be 1, 12-dihydroxyl, 6, 12, 17-tetraazacyclodocosane-2, 5, 13, 16-tetrone by spectroscopic analysis and X-ray crystallographic analysis. The molecule of bisucaberin consists of a cyclic dimer of 1-hydroxyl, 6-diazaundecane-2, 5-dione moiety and is closely related to nocardamine, the trimer of the same moiety.

Corresponding author

Register with J-STAGE for free!