ISOLATION, STRUCTURAL ELUCIDATION AND BIOLOGICAL PROPERTIES OF NEOENACTINS B₁, B₂, M₁, AND M₂, NEOENACTIN CONGENERS

Abstract

The structures of three neoenactin congeners, designated as neoenactins B₁, B₂ and M₂ were elucidated by ¹H and ¹³C NMR and mass spectroscopic studies. Another minor component, neoenactin M₁, isolated from the crude mixture, was identified as lipoxamycin. All three new compounds were structurally related to neoenactin A. While B₁ was proved to be a positional isomer of B₂, M₂ was found to be a dihydro derivative of A. All the compounds were active against yeasts and fungi and potentiated the activities of polyene antifungal antibiotics such as trichomycins A and B and amphotericin B.