The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
WF-3405, A NOVEL ANTITUMOR ANTIBIOTIC
TAXONOMY, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES
SUMIO KLYOTO, HLDETSUGU MURAI, YASUHISA TSURUMI, HLROSHI TERANO, MASANOBU KOHSAKA, SHIGEHIRO TAKASE, ITSUO UCHIDA, MASASHI HASHIMOTO, HATSUO AOKI, HIROSHI IMANAKA
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JOURNAL FREE ACCESS

1987 Volume 40 Issue 3 Pages 290-295

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Abstract

A new antitumor antibiotic, WF-3405 was isolated from the culture of Amauroascus aureus F-3405. The structure has been determined as 1, 5-dioxiranyl-1, 2, 3, 4, 5-pentanepentanol on the basis of spectroscopic and chemical evidence.
WF-3405 exhibits strong inhibitory activity against various murine tumors including leukemia P388, leukemia L1210 and Lewis lung carcinoma.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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