WF-3405, A NOVEL ANTITUMOR ANTIBIOTIC TAXONOMY, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

SUMIO KLYOTO; HLDETSUGU MURAI; YASUHISA TSURUMI; HLROSHI TERANO; MASANOBU KOHSAKA; SHIGEHIRO TAKASE; ITSUO UCHIDA; MASASHI HASHIMOTO; HATSUO AOKI; HIROSHI IMANAKA

doi:10.7164/antibiotics.40.290

WF-3405, A NOVEL ANTITUMOR ANTIBIOTIC

TAXONOMY, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

SUMIO KLYOTO, HLDETSUGU MURAI, YASUHISA TSURUMI, HLROSHI TERANO, MASANOBU KOHSAKA, SHIGEHIRO TAKASE, ITSUO UCHIDA, MASASHI HASHIMOTO, HATSUO AOKI, HIROSHI IMANAKA

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JOURNAL FREE ACCESS

1987 Volume 40 Issue 3 Pages 290-295

DOI https://doi.org/10.7164/antibiotics.40.290

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Abstract

A new antitumor antibiotic, WF-3405 was isolated from the culture of Amauroascus aureus F-3405. The structure has been determined as 1, 5-dioxiranyl-1, 2, 3, 4, 5-pentanepentanol on the basis of spectroscopic and chemical evidence.
WF-3405 exhibits strong inhibitory activity against various murine tumors including leukemia P388, leukemia L1210 and Lewis lung carcinoma.

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