BIOSYNTHETIC STUDIES ON VALIDAMYCINS

I. ¹H AND ¹³C NMR ASSIGNMENTS OF VALIDAMYCIN A

Abstract

The ¹H and ¹³C NMR spectra of validamycin A have been assigned by use of 2D homonuclear correlation spectroscopy for protons, and off-resonance decoupling, single frequency off-resonance decoupling, and comparison studies with model compounds for carbons. Effects of pH on carbon chemical shifts have also been studied.