HRE 664, A NEW PARENTERAL PENEM

I. ANTIBACTERIAL ACTIVITY IN VITRO

Abstract

The new penem antibiotic HRE 664 displays potent antibacterial activity in vitro against a broad spectrum of clinically relevant bacterial strains including Gram-negative and Grampositive aerobes and anaerobes.
With an MIC 90% of 0.43 μg/ml, it is also active against methicillin-resistant staphylococci. HRE 664 is extremely stable against β-lactamases, it binds preferentially to the penicillin-binding proteins 2, 3, 5 and 6 of Escherichia coli.