CV-1, A NEW ANTIBIOTIC PRODUCED BY A STRAIN OF STREPTOMYCES SP.

I. FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES OF THE ANTIBIOTIC

Abstract

A new antibiotic, CV-1, was isolated from the culture broth of a Streptomyces sp. by various chromatographies. CV-1 showed antibacterial activity against Escherichia coli in cooperation with spiramycin, a macrolide antibiotic. The mode of action of CV-1 seemed to be the inhibition of lipopolysaccharide synthesis.